The San Francisco 49ers visit the Indianapolis Colts in Week 16 of the 2025 NFL season. The game takes place at Lucas Oil Stadium on Monday, December 22, with kickoff at 8:15 PM. Fans can watch the action live on ESPN.
San Francisco comes into the game with a strong record of 10-4. They have performed well on the road, posting a 6-2 record away from home. Meanwhile, the Colts hold an 8-6 record, with an impressive 6-1 mark at home. The 49ers are favored with a moneyline of -283, while the Colts are at +232.
49ers Preview
The San Francisco 49ers have shown strong performance recently. They won their last three games, including a 37-24 win against the Tennessee Titans. The team has displayed a balanced attack in both passing and rushing yards.
Brock Purdy has been a standout player for the 49ers. In the recent game against the Titans, he threw for 295 yards and 3 touchdowns. His connection with George Kittle and Jauan Jennings has been effective.
The 49ers are dealing with several injuries. Key players like Nick Bosa and Fred Warner are out for the season. Despite the injuries, the team’s depth continues to provide strong performances.
Colts Preview
The Indianapolis Colts have had a tough stretch in their recent games. They lost to the Seahawks 18-16, with Philip Rivers throwing for 120 yards and one touchdown. Despite Jonathan Taylor’s solid performance with 87 rushing yards, the team struggled to secure a win.
In their earlier game against the Jaguars, the Colts lost 36-19. Riley Leonard stepped in as quarterback, throwing for 145 yards. Jonathan Taylor led the rushing attack with 74 yards and one touchdown.
The Colts’ only recent win was against the Titans, where they came out on top 38-14. Daniel Jones threw for 272 yards and three touchdowns. Jonathan Taylor was a key player again, rushing for 153 yards and two touchdowns.
Betting Prediction
The 49ers have one of the top passing offenses in the league. They ranked 4th in passing yards last season. The Colts struggle in defending the pass, ranking 29th in opponent offensive yards.
On defense, the 49ers are solid with their pass interceptions. They rank 9th in opponent passing interceptions. This could lead to turnovers against the Colts, who have a lower-ranked passing attack.
The Colts rank 23rd in opponent score, which indicates they allow many points. The 49ers offense is capable of putting up points with their 13th-ranked scoring. The spread of 6.0 favors the 49ers given these matchups.
- Pick: 49ers -6.0 (-113)
