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NFL Pick – Green Bay Packers vs San Francisco 49ers

Green Bay Visits Ailing Niners

Our Green Bay vs San Francisco pick has the Pack favored by 6.5 points. Green Bay comes to this game having won three of their last five. They last played on Sunday, losing to the Minnesota Vikings 28-22. The Forty-Niners come into tonight’s game having lost QB Jimmy Garoppolo and TE George Kittle. Both are out for numerous weeks. Over their last five games, San Fran is 2-3. Like the Packers, the 49ers lost their Sunday matchup when the Seattle Seahawks took them down 37-27. Kickoff for this November 5, 2020, Thursday Night Football game is scheduled for 8:20 pm ET. This contest will be played at Levi’s Stadium in Santa Clara, CA.

Green Bay vs San Francisco Pick – Offenses

Green Bay is averaging 31.3 PPG. The 49ers are putting up 26.0 PPG. Both team’s totals and breakdowns on offensive yardage are similar. The Packers and Niners are both rushing for close to 130 YPG and passing for about 270 YPG.

Green Bay

QB Aaron Rodgers has performed well this season, tossing 20 TD strikes and just two picks. Rodgers, who’s been sacked eight times, is completing 65.8% of his passes. His two favorite targets are WR Davante Adams and TE Robert Tonyan. They have 43 and 23 receptions respectively. Adams has caught seven touchdown passes and Tonyan has five. RB Aaron Jones, who’s listed as questionable, may be back on the field tonight. In five games, he’s made 57 carries for 389 yards and scored five TDs.

San Francisco

We expect three-year man Nick Mullens to get the call at quarterback. Last week against Seattle, Mullens threw 25 passes and completed 18 (72%). He tossed two TD passes and did not give up a pick. Another issue for this team is the receiving corps, which, along with Kittle, has lost Brandon Aiyuk and Deebo Samuel. Both were placed on the reserve/COVID-19 list. WR Kendrick Bourne, who has 25 catches for 352 yards and one score, will play. Also out are two of the teams top-three rushers, Jeff Wilson and Raheem Mostert. Jerick McKinnon, who has four TD runs and 209 yards on 47 carries, is ready to go.

Packers vs 49ers Spread Pick – Defenses

Our Green Bay vs San Francisco pick notes that the 49ers’ defense is a tad better than the Packers’. Green Bay is allowing opponents 26.7 PPG, while the Niners are giving up just 21.6. However, tonight, San Francisco will be without some defensive talent. The biggest concern is the possibility that safety Jaquiski Tartt may not play. However, many top performers are ready to go. Those include LB Fred Warner (61 TKLs, 3 PD, 2 INTs), corner Emmanuel Moseley (36 TKLs, 7 PD, 1 INT) and DE Kerry Hyder Jr. (25 TKLs, 4.5 SKs, 6 TFL).

The Packers are missing four players from their secondary, including safeties Raven Greene and Will Redmond and corner Kevin King. However, safeties Darnell Savage and Adrian Amos and corner Jaire Alexander are slated to play. Alexander has one INT, three PD, two TFL, and one sack. LB Za’Darius Smith is a major force. He comes to tonight’s game with six sacks, nine TFL, and one forced and recovered fumble. LB Krys Barnes leads the Pack in solo tackles (26) and assists (21).

Green Bay vs San Francisco Pick – Final Word

In conclusion, our Green Bay vs San Francisco pick finds that the Niners have an edge on defense, while the Packers look better tonight on offense. Which wins this game? We think that the offensive forces will dominate. Consequently, we think that the Green Bay Packers have the edge. As a result, we’re going with the Pack at -6.5. Make sure you check out our college football picks for today! We have the totals and spread for Utah State vs Nevada.

Green Bay Packers vs San Francisco 49ers Summary

Green Bay Packers at -6.5 (-103)


Paul has been writing about sports betting and sports for more than a decade, offering picks on the NFL, MLB, NHL, and NBA, as well as on college sports and European football. He's written thousands of season and post-season previews, innumerable articles on sports betting strategies, and various books on sports and sports betting.

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