San Francisco Giants vs Chicago Cubs – MLB Preview – Aug 26, 2025
The Chicago Cubs begin a three-game series against the San Francisco Giants on Tuesday night at Oracle Park. First pitch is scheduled for 9:45 PM ET. The Cubs enter with a 76-55 record, sitting firmly in the NL Central race, while the Giants come in at 63-68, fighting to stay alive in the Wild Card picture.
These two clubs met in early May at Wrigley Field, where Chicago took two out of three games, including a 9-2 win behind Matthew Boyd. The Giants earned a 3-1 win in the finale, but overall the Cubs have had the better of the head-to-head series in recent years. Both teams come into this matchup with something to prove—Chicago looking to keep pressure on Milwaukee, and San Francisco needing wins to climb back into contention.
CHC Preview – Boyd Looks to Stay Sharp
The Cubs are sending veteran left-hander Matthew Boyd to the mound. Boyd is 12-6 with a 2.61 ERA this season and was the winning pitcher in their May 5 meeting against the Giants. He threw six strong innings, allowing just two runs with seven strikeouts. This will be his first-ever start at Oracle Park in his 11-year career.
Offensively, Chicago has been on a hot streak. The Cubs have won six of their last seven games and started their West Coast trip with a sweep of the Angels. Kyle Tucker led the way in Los Angeles, hitting three home runs in a 19-run outburst. Craig Counsell’s lineup has shown improved balance, with several hitters finding their form late in August.
The Cubs bullpen has been one of their strengths, carrying a combined ERA under 3.00 in August. Brad Keller, Caleb Thielbar, and Daniel Palencia have been reliable options, while Drew Pomeranz has held opponents to a sub-2.00 ERA. The unit will be tested in this series, as Oracle Park has been tough on visiting teams, but Chicago comes in with plenty of momentum.
SF Preview – Verlander Chasing Milestone
San Francisco counters with veteran right-hander Justin Verlander. At 42 years old, Verlander is 1-10 with a 4.64 ERA this season, but he has historically pitched well against the Cubs. He is 2-0 with a 2.35 ERA in four career starts against them, and he needs just one strikeout to reach 100 for the season. That would mark his 17th career season with at least 100 strikeouts, tying Warren Spahn for 14th all-time.
The Giants are coming off a series win in Milwaukee, where they took two of three games against the Brewers. Shortstop Willy Adames hit a key home run in Sunday’s 4-3 victory, which gave San Francisco a boost heading into this homestand. However, the Giants have struggled at Oracle Park, losing 15 of their last 17 home games, something they must correct quickly if they want to stay in the playoff hunt.
Offensively, the Giants have been inconsistent. They average 4.05 runs per game, ranking in the lower half of MLB. Injuries have also been a factor, with key players like Luis Roupp, Erik Miller, and Jerar Encarnacion currently sidelined. The bullpen has been steady, posting a 3.22 ERA overall, led by Randy Rodriguez and Matt Gage, who have combined for strong late-inning performances. Still, scoring support has been their biggest issue at home.
Matchup Breakdown
Chicago comes in as the stronger all-around team. They are scoring nearly a full run more per game than the Giants, at 4.95 compared to 4.05. The Cubs also hold the edge in pitching, carrying a team ERA of 3.77 against San Francisco’s 3.75 but with better depth and more consistent arms. The Cubs’ bullpen ERA is 2.82, while the Giants’ sits at 3.22, giving Chicago another advantage in the late innings.
Head-to-head, the Cubs have won six of the last ten meetings. The over/under has split evenly in those games, going 6-4 to the over. Bettors should note that the Cubs are 59-61 O/U this year, while the Giants are 60-65, meaning both teams lean slightly to the under overall. However, Chicago’s recent offensive surge has pushed several of their games over the number.
The key matchup will be how Boyd handles a Giants lineup that has struggled for power. San Francisco has relied more on timely hits than home runs, and Boyd has been tough on left-handed bats all season. On the other side, the Cubs lineup will look to stay aggressive against Verlander, who has been hittable despite his experience and strikeout ability.
Betting Prediction
The Cubs opened as -135 favorites on the road, while the total sits at 7.5 runs. Chicago is 35-30 away from Wrigley Field this year, while San Francisco is 30-33 at home. The Cubs have also been strong in series openers, while the Giants have struggled to carry momentum back to Oracle Park.
Chicago’s stronger rotation, deeper bullpen, and red-hot lineup give them the edge in this matchup. San Francisco has the advantage of Verlander’s experience, but unless their offense comes alive, it will be tough to outlast Boyd and the Cubs’ pitching staff. Expect Chicago to take the opener behind Boyd, with the total leaning to the over given the Cubs’ recent offensive production. Predicted final score: Cubs 6, Giants 3.
Pick: Cubs -135, Over 7.5




